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Cubs vs Yankees Predictions, Best Bets, and Picks

The Chicago Cubs take on the New York Yankees in an interleague showdown this Saturday at Yankee Stadium. This article provides data‑driven Cubs vs Yankees Prediction, best bets, and a top AI Pick for savvy bettors.

Game Prediction

Chicago Cubs

Chicago Cubs

CHC

VS
Jul 12
Starts at
1:05 pm
Yankee Stadium, Bronx, NY
New York Yankees

New York Yankees

NYY

Jul 12
Starts at
1:05 pm
Yankee Stadium, Bronx, NY

Pre-game wagerbirds

Full game
Full Game Run Line: CHC +1.5
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52
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Full Game Game Total
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First Five Innings Game Total
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Betting Overview

  • Teams: Chicago Cubs @ New York Yankees
  • Date & Time: Saturday, July 12, 2025 – 1:05 PM ET
  • Venue: Yankee Stadium, The Bronx, NY
  • Broadcast: MLB Network, YES and MARQ

Betting Odds

  • Moneyline: Yankees –163, Cubs +136
  • Run Line: Yankees −1.5 (+130), Cubs +1.5 (–156)
  • Total: 8 runs (o/–114, u/–106)

Preview of Cubs vs Yankees Prediction

This matchup pits All-Star Carlos Rodón (Yankees) against the Cubs' Matthew Boyd. Rodón was recently named to the AL All-Star roster with a 3.30 ERA and 127 strikeouts over 111.2 innings. Boyd is delivering too—he carries a 2.52 ERA across nearly 104 innings.

Both lineups have shown vulnerabilities versus left-handed pitching, suggesting a tighter scoring affair

Injury & Storylines:

  • Yankees starter Max Fried is skipping the All-Star Game to prepare
  • Yankees recently placed high-leverage arm Fernando Cruz on the IL, impacting their bullpen depth
  • Cubs have key bullpen pieces absent—Jameson Taillon and Porter Hodge
  • Chicago offensively on fire: Pete Crow‑Armstrong hit his 25th homer and 25th stolen base, and Seiya Suzuki continues to produce

Cubs vs Yankees Predictions

Here are the WAGERBIRD Terminal picks for this matchup, based on algorithmic modeling and confidence scoring:

Free Pick

Full Game Run Line: CHC +1.5 — Confidence: 52

Gated Picks (Terminal Access Required)

  • Full Game Game Total — Confidence: 66
  • First Five Innings Game Total — Confidence: 54

**Unlock our full set of AI MLB picks with higher confidence in the WAGERBIRD Terminal.

FAQs

What chance does Chicago Cubs have of beating the Yankees?

Current moneyline odds (+136) imply roughly a 42.4% chance for the Cubs to pull off the upset.

How many times have the Cubs beaten the Yankees?

This is an early-season interleague series; last year’s matchups were split—no notable long-term series history applies here.

Who is favored to win Cubs vs Yankees?

The Yankees are favored across all lines—moneyline (−163), run line, and total—mainly due to Rodón’s form and home-field edge.

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