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Cardinals vs Rockies Predictions, Best Bets, and Picks

The St. Louis Cardinals head into Coors Field to face the struggling Colorado Rockies tonight. Uncover WAGERBIRD’s AI-powered MLB prediction, top bets, and in-depth pitching/offensive analysis before first pitch.

Game Prediction

St. Louis Cardinals

St. Louis Cardinals

STL

VS
Jul 22
Starts at
8:40 pm
Coors Field, Denver, CO
Colorado Rockies

Colorado Rockies

COL

Jul 22
Starts at
8:40 pm
Coors Field, Denver, CO

Pre-game wagerbirds

Full game
First Five Innings Game Total: U 6.5
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59
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Full Game STL Team Total
Confidence Rating:
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68
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Full Game Run Line
Confidence Rating:
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88
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Confidence Rating:
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Confidence Rating:
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Confidence Rating:
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Confidence Rating:
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Confidence Rating:
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Betting Overview

Teams: St. Louis Cardinals @ Colorado Rockies
Date/Time: Tuesday, July 22, 2025 · 8:40 PM ET
Venue: Coors Field, Denver, CO

Betting Odds

  • Moneyline: Cardinals –156, Rockies +130
  • Run Line: Cardinals −1.5 at −104, Rockies +1.5 at +117
  • Total (O/U): 12 runs — Over –112, Under –108
    All odds per Fox Sports

Preview of Cardinals vs Rockies Prediction

  • Lineup Strength:
    • Cardinals offense led by Alec Burleson, Brendan Donovan, and Nolan Arenado, averaging 4.3 runs/game but cooled lately (56.5% win rate as favorites)
    • Rockies continue to struggle severely, ranking among MLB’s worst, but recently snapped a long skid and won back-to-back in Colorado

  • Ballpark Factors: Coors Field remains the most hitter-friendly park in MLB, prone to extra scoring due to altitude and thin air
  • Injury Notes: Cardinals missing Lars Nootbaar and Nolan Gorman (both on IL); Rockies without key bats Kris Bryant, Thairo Estrada, and others

Expect a high-run game thanks to Coors Field’s altitude, despite lineup gaps due to injuries.

Cardinals vs Rockies Predictions

Our WAGERBIRD algorithm serves up the sharpest plays for this Coors Field showdown.

Free Pick

  • First Five Innings Game Total: U 6.5 - Confidence: 88

Gated Picks (Terminal Access Required)

  • Full Game STL Team TotalConfidence: 68
  • Full Game Run LineConfidence: 88

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FAQs

What chance do the Cardinals have of beating the Rockies?

Moneyline odds imply ~61% favorite; WAGERBIRD factors in park effects and injuries to model a win probability near 60%.

How have they lined up in recent meetings?

Cardinals recently upset the Rockies with a 6–2 win on July 21, snapping Colorado's rare two-game home streak.

Who is favored in this matchup?

St. Louis is favored in both moneyline (−156) and on the run line; however, Coors Field gives the Rockies a boost, making +1.5 key for WAGERBIRD’s model.

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