Cardinals vs Rockies Predictions, Best Bets, and Picks
The St. Louis Cardinals head into Coors Field to face the struggling Colorado Rockies tonight. Uncover WAGERBIRD’s AI-powered MLB prediction, top bets, and in-depth pitching/offensive analysis before first pitch.
Game Prediction
STL
COL
Pre-game wagerbirds










The rest are waiting in the terminal.
Betting Overview
Teams: St. Louis Cardinals @ Colorado Rockies
Date/Time: Tuesday, July 22, 2025 · 8:40 PM ET
Venue: Coors Field, Denver, CO
Betting Odds
- Moneyline: Cardinals –156, Rockies +130
- Run Line: Cardinals −1.5 at −104, Rockies +1.5 at +117
- Total (O/U): 12 runs — Over –112, Under –108
All odds per Fox Sports
Preview of Cardinals vs Rockies Prediction
- Lineup Strength:
- Cardinals offense led by Alec Burleson, Brendan Donovan, and Nolan Arenado, averaging 4.3 runs/game but cooled lately (56.5% win rate as favorites)
- Rockies continue to struggle severely, ranking among MLB’s worst, but recently snapped a long skid and won back-to-back in Colorado
- Ballpark Factors: Coors Field remains the most hitter-friendly park in MLB, prone to extra scoring due to altitude and thin air
- Injury Notes: Cardinals missing Lars Nootbaar and Nolan Gorman (both on IL); Rockies without key bats Kris Bryant, Thairo Estrada, and others
Expect a high-run game thanks to Coors Field’s altitude, despite lineup gaps due to injuries.
Cardinals vs Rockies Predictions
Our WAGERBIRD algorithm serves up the sharpest plays for this Coors Field showdown.
Free Pick
- First Five Innings Game Total: U 6.5 - Confidence: 88
Gated Picks (Terminal Access Required)
- Full Game STL Team Total – Confidence: 68
- Full Game Run Line – Confidence: 88
**Unlock our full set of MLB picks, model breakdowns, and confidence analytics inside the WAGERBIRD Terminal.
FAQs
What chance do the Cardinals have of beating the Rockies?
Moneyline odds imply ~61% favorite; WAGERBIRD factors in park effects and injuries to model a win probability near 60%.
How have they lined up in recent meetings?
Cardinals recently upset the Rockies with a 6–2 win on July 21, snapping Colorado's rare two-game home streak.
Who is favored in this matchup?
St. Louis is favored in both moneyline (−156) and on the run line; however, Coors Field gives the Rockies a boost, making +1.5 key for WAGERBIRD’s model.
Explore More Predictions Like Cardinals vs Rockies
- Access the full lineup of MLB insights in the WAGERBIRD Terminal
- Subscribe to our HOTSHEET for top-rated picks via SMS/email
- Use the AI parlay generator on PARLAY PUNCH for expertly crafted same-day parlays
Want more picks like this?
Get access to the full board—confidence-ranked picks across every major sport, updated in real time.